锁掷酵母破壁粉对乙醇诱导氧化损伤小鼠的抗氧化作用

he present work studied the anti-oxidation effect of S.pararoseus JD-2 power in ethanol-induced oxidative damage mice, aimed to explore the potential of S.pararoseus JD-2 power as an antioxidant functional food. ICR mice were intragastrically administered with different doses of S.pararoseus JD-2 power for 42 days. At the end of animal experiment,,, mice were given ethanol to cause oxidative damage model except the control group.Malonaldehyde (MDA), protein carbonyl (PC), glutathione (GSH) and superoxide dismutase (SOD) activity in serum,liver and brain tissues were determined. The results showed that compared with the model group, the blank group, 0.8g/(kgobw), and 1.6 g/(kgobw) dose groups significantly decreased MDA and PC conAntioxidant effect of S.pararoseus JD-2 power on ethanol-induced oxidative damage in micetents in serum, liver, and brain tissues (P < 0.05), significantly increased GSH content and SOD activity (P < 0.05). Therefore, the S.pararoseus JD-2 power has antioxidation effect on ethanol-induced oxidative damage in mice, which plays a role in reducing the content of MDA and PC of mice, increasing the content of GSH and increasing the activity of SOD. 0.8 g /(kgobw) is the minimum effective dose of S.pararoseus JD-2 power, and its efficacy component should be further studied.