一种pH响应生物矿化纳米颗粒的合成及其聚集诱导发光激活的光敏特性研究

novel calcium carbonate-modified photosensitive molecule for tumor acid response and photodynamic therapy is reported here. CaCO3 nanocarrier was prepared by using bovine serum protein as the skeleton for the first time and loaded with a new type of aggregation induced luminescence photosensitive molecule (TPE-Br). The TPE-loaded NPs have small sizes (100 ± 10 nm) with good water dispersion and stability. With the increase of acidity (pH=7.4-5.0), internal TPE-Br molecules are released gradually. The released molecules accumulate through hydrophobic interaction, fluorescing and generating photodynamic therapy under an external light source. The nanocarrier has good biocompatibility and biodegradability, and the internal TPE-Br molecule has good fluorescA pH-Responsive Biomineralized Nanoparticle Used for Aggregation-Induced Emission-activated Photosensitizerence imaging performance and photodynamic therapy performance. Cell experiments have confirmed the great potential of nanoparticles in tumor imaging and treatment, providing further guidance for diagnosis and treatment in mice.