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中药复明片对兔视网膜脱离后视网膜组织超微结构的影响

Effects of FuMing Tablets on retinal ultrastructure after retinal detachment of rabbits

中文摘要英文摘要

目的:研究益气养阴活血利水之复明片对兔实验性视网膜脱离后视网膜组织超微结构的影响。方法:将36只有色家兔随机分为正常对照组(A组)、模型组(B组)、西药对照组(C组)、复明片组(D组),每组9只。B、C、D组制作视网膜脱离模型。造模后第1d下午开始给药,A组与B组均予温开水灌胃,5ml/kg•体重,1次/d;C组予西药混合溶液灌胃,5ml/kg•体重,1次/d;D组予复明片混悬液灌胃,5ml/kg•体重,1次/d。并于造模后7,14,21d分别观察各组视网膜复位情况,取材后电镜下观察超微结构改变。结果:复明片能促进脱离视网膜复位,减轻脱离及复位视网膜组织及细胞的形态学损伤,改善视功能。结论:益气养阴活血利水之复明片通过抑制兔视网膜脱离后的细胞增殖、抑制炎症反应以及抑制基质的降解而起到保护视网膜组织结构、促进视网膜脱离后视功能恢复的作用。

Object: to investigate effects of FuMing Tablets(FMT) of qi-benefitting, yin-fostering, and blood- invigorating and diuresis-activating on retinal ultrastructure after retinal detachment of rabbits. Method: 36 rabbits were divided into normal contrast group (group A) , retinal detachment model group (group B), western medicine contrast group(group C),FMT group(group D).Each group had 9 rabbits.Group B,C,D were made retinal detachment model. After models were made one day they were given medicine. Group A and B were administrated intragastrically with 5ml/kg warm water ,once a day. Group C was administrated intragastrically with 5ml/kg western medicine solution, once a day. Group D was administrated intragastrically with 5ml/kg FMT suspension, once a day. After models were made to observe the retina recovery on the 7th, 14th, and 21st day, and the changes of ultrastructure with microscope . Result: FMT can promote the retinal reattachment, reduce the morphology damage of retina cells and tissue and improve sight. Conclusion: FuMing Tablets of qi-benefiting, yin-nourishing, blood-invigorating and diuresis-activating can protect retinal tissue structure and promote sight recovery by restraining the cells multiplication, inflammation and degradation of substrate.

彭俊、姚小磊、彭清华、刘娉

眼科学基础医学中医学

复明片益气养阴活血利水法视网膜脱离模型视网膜色素上皮细胞组织结构

FuMing Tabletsmethod of qi-benefittingyin-fostering and blood- invigorating and diuresis-activatingretinal detachment modelretina pigment epidermis cellstissue structurerabbit

彭俊,姚小磊,彭清华,刘娉.中药复明片对兔视网膜脱离后视网膜组织超微结构的影响[EB/OL].(2010-01-13)[2025-08-16].http://www.paper.edu.cn/releasepaper/content/201001-514.点此复制

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