Disruption of Human astn2 Function by ZIKV ns4b Gene as a Molecular Basis for Zika Viral Microcephaly
Disruption of Human astn2 Function by ZIKV ns4b Gene as a Molecular Basis for Zika Viral Microcephaly
ABSTRACT The present Zika virus (ZIKV) pandemic is being associated with increased incidence of microcephaly in newborns. However, a molecular basis for such pathogenesis is distinctly lacking. Comparative nucleic acid sequence analysis showed similarity between regions of non-structural protein 4B (ns4b) gene of ZIKV and human astrotactin2 (astn2) gene. Based on these findings, a molecular target of Zika viral microcephaly is being proposed.
Ganguly Bhaskar、Ganguly Enakshi
Animal Biotechnology Center, Department of Veterinary Physiology andBiochemistry, College of Veterinary and Animal Sciences, G. B. Pant University of Agriculture and TechnologyDepartment of Community Medicine, MediCiti Institute of Medical Sciences,
基础医学分子生物学神经病学、精神病学
Zika virusmicrocephalyastrotactin 2ns4bparsimonypathogenesis
Ganguly Bhaskar,Ganguly Enakshi.Disruption of Human astn2 Function by ZIKV ns4b Gene as a Molecular Basis for Zika Viral Microcephaly[EB/OL].(2025-03-28)[2025-05-25].https://www.biorxiv.org/content/10.1101/054486.点此复制
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