复方浙贝颗粒联合阿霉素对K562/A02移植瘤抑瘤率影响研究

Objective To investigate the drug-combination of Compound Zhe Bei Granule (CZBG) and doxorubicin effects on the inhibition of K562/A02 multidrug resistance tumor xenografts. Method Tumor xenografts model were established by injecting the Multidrug resistance cell lines K562/A02 in the axillary flank of BALB/c-nu-nu mice. The volume and weight of tumor xenografts were measured in the experiment, simultaneously, the inhibition rate of tumor xenografts were calculated according to the data after the dissection. Results In the groups of the combination of the doxorubicin and CZBG with dosage classified by three types(high, middle, low), the volume and weight all showed statistical significance compared with the normal saline control group（p<0.05）. In the groups of high-dosage and middle-dosage, the inhibition of tumor exnografts also showed statistical significance compared with doxorubicin positive control group. Conclusion The drug-combination of CZBG (high-dosage and middle-dosage) and doxorubicin can enhance the sensitivity of multidrug resistance cells K562/A02 to the doxorubicin.