IgG糖基化与类风湿性关节炎关联研究的系统综述

Background Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by multiple symmetrical erosive arthritis. IgG glycosylation has been shown to play a role in various immune processes and has been associated with the onset and progression of RA. Objective To systematically review the relationship between IgG glycosylation and RA, and offer insights for the development of RA preventive strategies. Methods We conducted a systematic review for researches on the association between IgG glycosylation and RA in PubMed, Web of Science, CNKI, Wanfang Database, and Weipu Database as of May 1, 2024. The quality of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) framework. Results A total of 469 relevant studies were identified, and 45 studies were included in this systematic review. The exposure factors in these studies were IgG glycosylation levels, and the outcomes included preclinical RA, RA transition, early RA, established RA, RA activity levels, RA remission, and RA during pregnancy. The results of GRADE indicated that most of the evidence provided was of low to moderate quality (88.9%). Conclusion This systematic review revealed that IgG glycosylation and its derived structures were associated with RA and demonstrated predictive capabilities in identifying RA and evaluating the therapeutic outcomes in RA treatment. However, for more precise conclusions, future research should prioritize high-quality, large-scale randomized controlled trials.