基于正交设计的磷钨酸柱撑水滑石催化合成乙酸正丁酯

n-butyl acetate catalyzed was synthesized with acetic acid and n-butanol as raw material and phosphotungstic acid Pillar Double Hydroxides as catalyst, the effects of reaction conditions on esterification rate were investigated by orthogonal experimental design. The result was systematic analyzed by intuitive analysis and variance analysis on the orthogonal design theory， the significance of the parameters and optimization results were found out. The results show that the molar ratio of acetic acid and n-butanol was 1 to 1.3, the quantity of phosphato-tungstic heteropolyacid catalyst accounting for the total material was 1.5%, the reaction temperature and time were 120℃ and 3h. The esterification rate could reach 98.0%. It was found out that phosphotungstic acid Pillar Double Hydroxides had good reusability and could be regenerated by activation, and it was a novel environment-friendly catalyst with good stability and selectivity.