Neuropsychological and neuroanatomical features of patients with behavioral variant Alzheimer’s disease (AD): a comparison to behavioral variant frontotemporal dementia and amnestic AD groups
Neuropsychological and neuroanatomical features of patients with behavioral variant Alzheimer’s disease (AD): a comparison to behavioral variant frontotemporal dementia and amnestic AD groups
ABSTRACT An understudied non-amnestic variant of Alzheimer’s disease (AD), behavioral variant AD (bvAD) is associated with progressive personality, behavior, or executive dysfunction and frontal atrophy. This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), amnestic AD (aAD), and subjects with normal cognition. Subjects included 16 bvAD, 67 bvFTD, and 18 aAD patients, and 26 healthy controls. Compared to bvFTD, bvAD showed more significant visuospatial impairments (Rey Figure copy and recall), more irritability (Neuropsychological Inventory), and equivalent verbal memory (Philadelphia Verbal Learning Test). Compared to aAD, bvAD indicated more executive dysfunction (F-letter fluency) and better visuospatial performance. Neuroimaging analysis found that bvAD showed cortical thinning relative to bvFTD posteriorly in left temporal-occipital regions; bvFTD had cortical thinning relative to bvAD in left inferior frontal cortex. bvAD had cortical thinning relative to aAD in prefrontal and anterior temporal regions. All patient groups had lower volumes than controls in both anterior and posterior hippocampus. However, bvAD patients had higher average volume than aAD patients in posterior hippocampus and higher volume than bvFTD patients in anterior hippocampus after adjustment for age and intracranial volume. Findings demonstrated that underlying pathology mediates disease presentation in bvAD and bvFTD.
Phillips Jeffrey S.、Rascovsky Katya、McMillan Corey T.、Kallogjeri Dorina、Grossman Murray、Wisse Laura E.M.、Vaddi Prerana、Yushkevich Paul A.、Xie Long、Irwin David J.、Perez Sophia Dominguez、Cousins Katheryn A.Q.、Halpin Amy、Norise Catherine、Kinney Nikolas G.
Penn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of PennsylvaniaPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of PennsylvaniaPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of PennsylvaniaDepartment of Otolaryngology, Washington UniversityPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of PennsylvaniaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania||Penn Image Computing and Science Lab & Department of Radiology, Perelman School of Medicine, University of Pennsylvania||Department of Diagnostic Radiology, Lund UniversityPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of PennsylvaniaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania||Penn Image Computing and Science Lab & Department of Radiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania||Penn Image Computing and Science Lab & Department of Radiology, Perelman School of Medicine, University of PennsylvaniaPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of Pennsylvania||Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of MedicinePenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of Pennsylvania||Department of Psychological Sciences, University of ConnecticutPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of PennsylvaniaPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of Pennsylvania||Department of Psychology, University of MaineDepartment of Neurology, Perelman School of Medicine, University of PennsylvaniaPenn Frontotemporal Degeneration Center (FTDC), University of Pennsylvania||Department of Neurology, Perelman School of Medicine, University of Pennsylvania
神经病学、精神病学基础医学医学研究方法
bvADfvADfrontal variantdysexecutivebehavioralbvFTDADCSFcognitive domainsneuropsychiatric symptomscortical thinninghippocampal volumes
Phillips Jeffrey S.,Rascovsky Katya,McMillan Corey T.,Kallogjeri Dorina,Grossman Murray,Wisse Laura E.M.,Vaddi Prerana,Yushkevich Paul A.,Xie Long,Irwin David J.,Perez Sophia Dominguez,Cousins Katheryn A.Q.,Halpin Amy,Norise Catherine,Kinney Nikolas G..Neuropsychological and neuroanatomical features of patients with behavioral variant Alzheimer’s disease (AD): a comparison to behavioral variant frontotemporal dementia and amnestic AD groups[EB/OL].(2025-03-28)[2025-08-06].https://www.medrxiv.org/content/10.1101/2022.01.04.21268578.点此复制
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