有机硒对羔羊机体硒状态及细胞因子水平的影响

Objective: To investigate the influence of organic selenium on the selenium status and cytokine levels in lambs. Methods: Thirty-two healthy lambs of Tan sheep were divided into 3 groups, one served as control (C) group. Two were supplemented different selenium sources namely selenium-enriched probiotics (T1 group) or sodium selenite (T2 group), respectively. The experiment lasted for 60 days. Blood samples were collected at 30-day intervals and tissue samples were collected at experiment termination. Tissues Se contents, blood glutathione peroxidase (GSH-PX) activity and serum cytokines levels were determined, respectively. Results: Blood GSH-Px activity and tissue Se contents in T1 group were higher (P＜0.0l) than those in control and T2 groups. Serum IL-1, IL-2, IL-6 and TNF-αcontents in T1 group were higher (P＜0.01 or P＜0.05)than those in control group. And there were no significant differences in the increase of serum IL-1, IL-2, IL-6 and TNF-α contents between T1 and T2 groups. Conclusion: Compared to inorganic Se, organic Se were more effective in increasing tissue Se contents and whole blood GSH-Px activities of lambs. No significant differences in increasing serum cytokine levels of lambs were found betweenorganic and inorganic Se.