K1在肝脏疾病中的研究进展

ITransforming growth factor-β-activated kinase 1 (TAK1) is a important adaptor protein for intracellular signaling transduction. It belongs to Serine/threonine protein kinase and has similar function and amino acid sequences as other members of Mitogen-activated protein kinase kinase kinaser (MAPKKK, MAP3K) family. It is also called MAP3K7 or MEKK7. The biological function of TAK1 has been characterized as a key regulator in cell proliferation, differentiation, survival and apoptosis, as well as inflammatory and immune signaling pathways. Recently, TAK1 was found to be involved in the development and progression of liver diseases. This review highlights the TAK1-mediated signaling pathway and physiological functions of TAK1 in hepatocellular carcinoma, hepatic fibrosis, hepatosteatosis, and chronic hepatitis B.