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首页|Investigating the interaction between white matter and brain state on tDCS-induced changes in brain network activity

Investigating the interaction between white matter and brain state on tDCS-induced changes in brain network activity

Investigating the interaction between white matter and brain state on tDCS-induced changes in brain network activity

来源:bioRxiv_logobioRxiv
英文摘要

Abstract BackgroundTranscranial direct current stimulation (tDCS) is a form of noninvasive brain stimulation whose potential as a cognitive therapy is hindered by our limited understanding of how participant and experimental factors influence its effects. Using functional MRI to study brain networks, we have previously shown in healthy controls that the physiological effects of tDCS are strongly influenced by brain state. We have additionally shown, in both healthy and traumatic brain injury (TBI) populations, that the behavioral effects of tDCS are positively correlated with white matter (WM) structure. ObjectivesIn this study we investigate how these two factors, WM structure and brain state, interact to shape the effect of tDCS on brain network activity. MethodsWe applied anodal, cathodal and sham tDCS to the right inferior frontal gyrus (rIFG) of healthy (n=22) and TBI participants (n=34). We used the Choice Reaction Task (CRT) performance to manipulate brain state during tDCS. We acquired simultaneous fMRI to assess activity of cognitive brain networks and used Fractional Anisotropy (FA) as a measure of WM structure. ResultsWe find that the effects of tDCS on brain network activity in TBI participants are highly dependent on brain state, replicating findings from our previous healthy control study in a separate, patient cohort. We then show that WM structure further modulates the brain-state dependent effects of tDCS on brain network activity. These effects are not unidirectional – in the absence of task with anodal and cathodal tDCS, FA is positively correlated with brain activity in several regions of the default mode network. Conversely, with cathodal tDCS during CRT performance, FA is negatively correlated with brain activity in a salience network region. ConclusionsOur results show that experimental and participant factors interact to have unexpected effects on brain network activity, and that these effects are not fully predictable by studying the factors in isolation.

Li Lucia M.、Kurtin Danielle L.、Leech Robert、Patel Maneesh C.、Sharp David J.、Violante Ines R.、Carmichael David W.、Zimmerman Karl、Hampshire Adam

Computational, Clinical, and Cognitive Neuroimaging Laboratory, Department of Medicine, Imperial College London||Imperial UK Dementia Research Initiative in Care and NeurotechnologyComputational, Clinical, and Cognitive Neuroimaging Laboratory, Department of Medicine, Imperial College LondonCentre for Neuroimaging Science, King?ˉs College LondonComputational, Clinical, and Cognitive Neuroimaging Laboratory, Department of Medicine, Imperial College LondonComputational, Clinical, and Cognitive Neuroimaging Laboratory, Department of Medicine, Imperial College London||Imperial UK Dementia Research Initiative in Care and NeurotechnologyNeuromodulation Laboratory, Department of Psychology, University of SurreyDepartment of Biomedical Imaging, King?ˉs College London, 3rd Floor Lambeth Wing, St Thomas?ˉ HospitalComputational, Clinical, and Cognitive Neuroimaging Laboratory, Department of Medicine, Imperial College LondonComputational, Clinical, and Cognitive Neuroimaging Laboratory, Department of Medicine, Imperial College London||Department of Biomedical Imaging, King?ˉs College London, 3rd Floor Lambeth Wing, St Thomas?ˉ Hospital

10.1101/2020.10.09.332742

神经病学、精神病学基础医学医学研究方法

default mode networkmagnetic resonance imagingsalience networkstimulationtraumatic brain injurywhite matter structure

Li Lucia M.,Kurtin Danielle L.,Leech Robert,Patel Maneesh C.,Sharp David J.,Violante Ines R.,Carmichael David W.,Zimmerman Karl,Hampshire Adam.Investigating the interaction between white matter and brain state on tDCS-induced changes in brain network activity[EB/OL].(2025-03-28)[2025-05-17].https://www.biorxiv.org/content/10.1101/2020.10.09.332742.点此复制

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