无模板法制备载肝素的聚电解质微囊及其表征

In this study we prepared a kind of core/shell microcapsule by using the electrostatic interactions among PAH/ HPO42-/Heparin molecules through template-free method without any help of emulsifiers. Scanning electron microscopy, confocal laser scanning microscopy, and laser doppler anemometry were used to characterize the microcapsules. It was shown that the microcapsules coating with heparin were monodisperse, size-controlable , had a core/shell structure. Coomassie brilliant blue and rhodamine B were chosen as model drugs to study the capsules` carrying ability of different electric charge molecules. This is a facile method with good repetitiveness and the microcapsules promise great potential use in the drug control release field.