Griffiths精神发育评估量表中文版评估丙戊酸钠、奥卡西平、左乙拉西坦对癫痫患儿不同能区发育的影响

Background ?Epilepsy is a chronic episodic brain disorder with a high incidence and can seriously affect the quality of life of the patients. Thereforetimely treatment to control seizures is particularly important. Numerous studies have shown the effect of antiepileptic drugs on cognitionbut there are few studies on the effects of different functional areas in children. Objective ?To explore the effects of sodium valproateVPAoxcarbazepineOXCand levetiracetamLEVon the development of different functional areas in children with focal epilepsy by Griffiths Development Scales-Chinese EditionGDS-C. Methods ?A total of 83 children with focal epilepsy who attended in outpatient and ward of the Department of Pediatric Neurology of the Third Affiliated Hospital of Zhengzhou University for the first time from January 2021 to April 2022 were selected as the trial groupand randomly divided into VPA groupOXC group and LEV group according to the random number table method30 healthy children who were examined during the same period were selected as the control group. The changes of EEG interictal epileptiform activityIEAbefore and after 6 months of treatment were recorded and the clinical effect was evaluated according to seizure frequencythe GDS-C was used to evaluate the development quotient of each functional area in the children. Results ?The total clinical effective rates of VPA groupOXC group and LEV group were 92.3%89.3% and 92.9%with no significant difference among the three groupsχ2=0.418P=1.000. The total EEG IEA effective rate of the VPA groupOXC group and LEV group were 88.5%57.1% and 89.3%with significant differences among the three groupsχ2=11.152P=0.004the total effective rate of EEG IEA in OXC group was lower than that in VPA group and LEV groupP<0.05. Before treatmentthere were statistically significant differences in the the development quotient of each dimension among four groupsP<0.05the development quotient of each dimension in three groups were lower than that in the control groupP<0.05. After treatmentthere were significant differences in the the development quotients of sportspersonal-socialhand-eye coordination and performance dimensions among VPA groupOXC group and LEV groupP<0.05the development quotients of sports and personal-social dimensions in LEV group were higher than VPA groupP<0.05the development quotients of personal-socialhand-eye coordination and performance dimensions in LEV group were higher than OXC groupP0.05. Compared to the pre-treatment periodthe development quotients of personal-social and practical reasoning dimensions significantly decreased in VPA groupP<0.05the development quotients of personal-sociallanguagehand-eye coordinationperformance and practical reasoning dimensions significantly increasedP<0.05.Conclusion ?VPAOXC and LEV are all effective in the treatment of focal epilepsy in childrenand all three have quivalent efficacyIn terms of improving EEG IEAOXC is inferior to VPA and LEVVPA may have a negative effect on personal-socialand practical reasoning dimensionsOXC has little effectand LEV may have improvement on personal-sociallanguagehand-eye coordinationperformancepractical reasoning dimensions.