LR7和NF-κB在外阴硬化性苔藓及外阴鳞癌中的表达及意义
Expression of TLR7 and NF-κB p65 in Vulvar Lichen Sclerosis and Vulvar Squamous Cell Carcinoma and Its Significance
目的：探讨TLR7和NF-κB p65在外阴硬化性苔癣和外阴鳞癌中的表达及意义。方法：采用免疫组化S-P法检测TLR7和NF-κB p65在外阴硬化性苔鲜及外阴鳞癌中的表达情况。结果：TLR7在外阴硬化性苔藓中的表达明显低于外阴正常皮肤（P<0.05）;NF-κB p65在外阴鳞癌中的表达明显高于外阴正常皮肤（P<0.05），其在外阴硬化性苔藓中的表达明显低于外阴正常皮肤（P<0.05）。结论：TLR7参与正常外阴表皮的免疫应答反应，在外阴硬化性苔藓中TLR7的作用减弱；NF-κB p65在外阴鳞癌中高表达，促进肿瘤细胞的增殖，在外阴硬化性苔藓中低表达，提示细胞增殖缓慢。结论：TLR7、NF-κB p65在外阴硬化性苔癣和外阴鳞癌发生、发展中发挥重要作用。
Objective: To investigate the expression of TLR7 and NF-κB p65 in vulvar squamous cell carcinoma and vulvar lichen sclerosus and its significance. Method: Immunohistochemic staining was conducted to detect the expression of TLR7 and NF-κB p65 in vulvar lichen sclerosus and vulvar squamous cell carcinoma. Results: TLR7 expression was significantly lower in vulvar lichen sclerosus than in normal vulva tissues（P<0.05）. NF-κB p65 expression was significantly higher in in vulva squamous cell carcinoma tissues than in normal vulva tissues（P<0.05）.NF-κB p65 expression was significant lower in vulvar lichen sclerosus than in normal vulva tissues（P<0.05）. Conclusion:TLR7 participated in the normal vulvar epidermal immune responses.Effection of TLR7 weakened in vulvar lichen sclerosus.High expression of NF-κB p65 in the vulvar squamous cell carcinoma promoted the proliferation of tumor cells.Low expression of NF-κB p65 in vulvar lichen sclerosus suggested the cell proliferation was slow.
武昕、赵毅、姚瑾、姜英
肿瘤学妇产科学基础医学
外阴鳞癌外阴硬化性苔藓LR7NF-κB p65免疫组化
Vulvar Squamous Cell CarcinomaVulvar Lichen SclerosusTLR7NF-κB p65Immunohistochemistry
武昕,赵毅,姚瑾,姜英.LR7和NF-κB在外阴硬化性苔藓及外阴鳞癌中的表达及意义[EB/OL].(2012-11-27)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201211-478.点此复制
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