脑缺血与血脑屏障相关性研究进展

Blood brain barrier(BBB) is a complicated cell system lying between brain tissue and blood. Its distinct anatomical characteristics can keep the homeostasis on the physiological condition, while the destroy of BBB is a central axis of initiating a series of brain tissue damage. Recent years’ study indicate that many kinds of materials, such as fibrinolysin, gelatinase, free radical, aquaporin protein, vasoactive substance, endothelin and gliocyte, participate in the changes of construction and function, and then participate in a series of pathological change after cerebral ischemia.