miRNA在胶质母细胞瘤中靶向治疗的研究进展

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults. Despite aggressive surgical resection and conventional chemoradiotherapy, the patients still has a dismal prognosis. Currently, targeting specific molecular to overcome the default to conventional therapy is becoming a hot area of research. MicroRNAs (miRNAs) is a kind of small non-coding RNAs and represent endogenous agents of RNA interference, which can significantly change the target proteins expressions. Their role in central nervous system diseases including GBM progression has attracted intense research effort towards therapeutic potential and targeting for sensitization of glioma cells to chemo and/or radiotherapy. This paper will review briefly the role of miRNAs in gliomagenesis and the association with patients' prognosis, as well as the potential application of selected miRNAs as therapeutic targets or agents in GBM.