Manufacturer Signal-to-Cutoff Threshold Underestimates Cumulative Incidence of SARS-CoV-2 Infection: Evidence from the Los Angeles Firefighters Study
Manufacturer Signal-to-Cutoff Threshold Underestimates Cumulative Incidence of SARS-CoV-2 Infection: Evidence from the Los Angeles Firefighters Study
Abstract While SARS-CoV-2 serologic testing is used to measure cumulative incidence of COVID-19, appropriate signal-to-cut off (S/Co) thresholds remain unclear. We demonstrate S/Co thresholds based on known negative samples significantly increases seropositivity and more accurately estimates cumulative incidence of disease compared to manufacturer-based thresholds.
Hori Acacia M.、Bhattacharya Jay、Sobhani Kimia、Sood Neeraj、Berg Anders H.、Toubat Omar、Mulligan Karen
University of Southern California||Cedars-Sinai Medical CenterCedars-Sinai Medical CenterUniversity of Southern CaliforniaCedars-Sinai Medical CenterUniversity of Southern CaliforniaUniversity of Southern California
医学研究方法基础医学预防医学
COVID-19SARS-CoV-2seroprevalenceserology
Hori Acacia M.,Bhattacharya Jay,Sobhani Kimia,Sood Neeraj,Berg Anders H.,Toubat Omar,Mulligan Karen.Manufacturer Signal-to-Cutoff Threshold Underestimates Cumulative Incidence of SARS-CoV-2 Infection: Evidence from the Los Angeles Firefighters Study[EB/OL].(2025-03-28)[2025-05-01].https://www.medrxiv.org/content/10.1101/2021.04.20.21255829.点此复制
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