茶多酚对乳腺癌组织及重要器官微血管密度影响研究
Observation on express of microvessle density in tumor tissue and vital organs tissue of tea polyphenols on implanted breast cancer
目的 观察茶多酚对小鼠乳腺癌组织及重要脏器（心、脑、肾）组织中微血管密度（MVD）表达影响，用以判定茶多酚抗肿瘤新生血管形成特异性。方法 应用小鼠可移植性乳腺癌EMT6细胞株，经培养传代后，以纯系BALB/c小鼠为荷瘤动物，并以茶多酚灌胃及局部注射两种干预方法，以免疫组化法检测小鼠乳腺癌组织和重要脏器（心、脑、肾）组织微血管密度（MVD）。结果 茶多酚灌胃组、局部注射组肿瘤组织MVD较模型组明显减少（P<0.05）；心、脑、肾组织MVD在茶多酚灌胃组、局部注射组与模型组比较无明显差异（P>0.05）。结论 茶多酚可选择性的抑制乳腺癌组织微血管生成，对重要脏器（心、脑、肾）组织无显著的影响。
Objective To observe the effect of microvessel density expressed in tumor tissue and vital organs(such as heart,brain,keney) on implanted mouse breast cancer treated by tea polyphynols, then judge the spencificity of its inhibiting angiogenesis effect. Methods Mammary adenocarcinoma EMT6 was cultured and propagated, then implanted on female BALB/c mice. Tea polyphenols was peroral administrated and local injected, microvessel density in tumor tusuue and vital organs(heart, brain,keney) was detected by immunohistochemical method. Result The express of microvessel density in tumor tissue of local injection group and peroral administrated group decreased compared with model group(P<0.05), while the express of microvessel density in heart, brain and kidney in treated group is of no significant difference compared with model group(P>0.05). Conclusion Tea polypynols can selectively inhibit the information of microvessel of breast cancer in tumor tissue and hav
徐力、张燕明、陈信义
肿瘤学基础医学药学
茶多酚小鼠乳腺癌微血管密度（MVD）脏器组织
ea polyphenols Breast cancer（EMT6） Microvessel density（MVD）
徐力,张燕明,陈信义.茶多酚对乳腺癌组织及重要器官微血管密度影响研究[EB/OL].(2007-02-03)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/200702-40.点此复制
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