oll样受体与抗病毒免疫
oll-like receptors and anti-virus immune
oll样受体(Toll-like receptors，TLRs)在天然免疫中发挥重要作用。研究表明TLRs也参与了天然免疫系统对病毒的识别，同时它在病毒感染及其转归中也扮演了重要角色。TLRs如同天然免疫的“眼睛”，监视与识别病原相关分子模式(pathogen associated molecular parrerns, PAMPs)，启动TLRs及其下游信号转导通路，发挥固有免疫抗病毒防御机制，同时也参与调控针对病毒的特异性免疫应答。激活的TLRs既可促进机体抗病毒保护免疫反应,也可恶化病毒诱导的疾病。本文综述了TLRs与病毒的相互作用以及在病毒感染中的正负反馈调节作用,对深入了解病毒的致病机制和发展抗病毒疗法具有指导意义。
oll-like receptors (TLRs) play an important role in innate immunity. Studies have shown that TLRs are also involved in the natural immune system to recognize the virus, while it is a virus infection and its prognosis has also played an important role. Innate immune TLRs, as the \"eyes\" to monitor and identify pathogen-associated molecular patterns (pathogen associated molecular parrerns, PAMPs), start the TLRs and their downstream signal transduction pathways play an innate immune antiviral defense mechanisms, but also involved in the control against the virus specific immune response. Activation of TLRs can promote the body\
周红光、吴勉华
基础医学生物科学理论、生物科学方法分子生物学
oll样受体病毒抗病毒免疫
oll-like receptorvirusanti-viral immunity
周红光,吴勉华.oll样受体与抗病毒免疫[EB/OL].(2010-01-08)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201001-333.点此复制
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