Subcortical Shape Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group
Subcortical Shape Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group
Abstract Alterations in regional subcortical brain volumes have been widely investigated as part of the efforts of an international consortium, ENIGMA, to determine reliable structural brain signatures for Major Depressive Disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work to precisely map localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subcortical structures: nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, and thalamus. Harmonized data processing and statistical analyses were conducted locally at each site, and findings were aggregated by meta-analysis. Relative to CTL, patients with MDD had lower surface area in the subiculum of the hippocampus, the basolateral amygdala, and the nucleus accumbens shell. Relative to CTL, patients with adolescent-onset MDD (≤ 21 years) had lower thickness and surface area of the subiculum of the hippocampus and the basolateral amygdala. Relative to first-episode MDD, recurrent MDD patients had lower thickness and surface area in the CA1 of the hippocampus and the basolateral amygdala. Our results suggest that previously reported MDD-associated volumetric differences may be localized to specific subfields of these structures that have been shown to be sensitive to the effects of stress, with important implications for mapping treatments to patients based on specific neural targets and key clinical features.
Schmaal Lianne、Gotlib Ian H.、Stein Dan J.、Walter Martin、S?mann Philipp G.、V?lzke Henry、Kircher Tilo、Veer Ilya、Pozzi Elena、Grabe Hans J.、Hosten Norbert、Wittfeld Katharina、Groenewold Nynke A.、Veltman Dick J.、Jahanshad Neda、Li Meng、Aleman Andr¨|、Dinga Richard、Ho Tiffany C.、Schnell Knut、Meinert Susanne、Krug Axel、Baune Bernhard、Jansen Andreas、Redlich Ronny、Sacchet Matthew D.、Gutman Boris、Nenadic Igor、Grotegerd Dominik、Opel Nils、Thompson Paul M.、F?rster Katharina、Dannlowski Udo、Walter Henrik
Orygen, The National Centre of Excellence in Youth Mental Health||Centre for Youth Mental Health, The University of MelbourneDepartment of Psychology, Stanford UniversityDepartment of Psychiatry and Mental Health, University of Cape TownDepartment of Psychiatry, University TuebingenDepartment of Psychiatry, Max Planck InstituteInstitute for Community Medicine, University Medicine GreifswaldDepartment of Psychiatry, Philipps-University MarburgDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of HealthMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health||Orygen, The National Centre of Excellence in Youth Mental HealthDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany and German Centre of Neurodegenerative Diseases (DZNE) site Greifswald/RostockDepartment of Diagnostic Radiology and Neuroradiology, University Medicine GreifswaldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Germany and German Centre of Neurodegenerative Diseases (DZNE) site Greifswald/RostockUniversity of Groningen, University Medical Center Groningen, Department of Neuroscience, Groningen||University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE)Department of Psychiatry, Amsterdam University Medical Centers, VU University Medical CenterImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck USC School of MedicineMax Planck Institute for Biological CyberneticsUniversity of Groningen, University Medical Center Groningen, Department of Neuroscience, GroningenDepartment of Psychiatry, Amsterdam University Medical Centers, VU University Medical CenterDepartment of Psychiatry & Behavioral Sciences, Stanford University||Department of Psychology, Stanford UniversityDepartment of Psychiatry and Psychotherapy, University Medical Center G?ttingenDepartment of Psychiatry, University of M¨1nsterDepartment of Psychiatry, Philipps-University MarburgDepartment of Psychiatry, University of M¨1nster||Department of Psychiatry, Melbourne Medical School, The University of MelbourneDepartment of Psychiatry, Philipps-University MarburgDepartment of Psychiatry, University of M¨1nsterDepartment of Psychiatry & Behavioral Sciences, Stanford UniversityDepartment of Biomedical Engineering, Illinois Institute of TechnologyDepartment of Psychiatry, Philipps-University MarburgDepartment of Psychiatry, University of M¨1nsterDepartment of Psychiatry, University of M¨1nsterImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck USC School of MedicineDepartment of Psychiatry, University of M¨1nsterDepartment of Psychiatry, University of M¨1nsterDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charit¨| - Universit?tsmedizin Berlin, corporate member of Freie Universit?t Berlin, Humboldt-Universit?t zu Berlin, and Berlin Institute of Health
神经病学、精神病学基础医学医学研究方法
Major Depressive Disorder (MDD)hippocampusamygdalanucleus accumbensshape analysisENIGMA
Schmaal Lianne,Gotlib Ian H.,Stein Dan J.,Walter Martin,S?mann Philipp G.,V?lzke Henry,Kircher Tilo,Veer Ilya,Pozzi Elena,Grabe Hans J.,Hosten Norbert,Wittfeld Katharina,Groenewold Nynke A.,Veltman Dick J.,Jahanshad Neda,Li Meng,Aleman Andr¨|,Dinga Richard,Ho Tiffany C.,Schnell Knut,Meinert Susanne,Krug Axel,Baune Bernhard,Jansen Andreas,Redlich Ronny,Sacchet Matthew D.,Gutman Boris,Nenadic Igor,Grotegerd Dominik,Opel Nils,Thompson Paul M.,F?rster Katharina,Dannlowski Udo,Walter Henrik.Subcortical Shape Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group[EB/OL].(2025-03-28)[2025-05-02].https://www.biorxiv.org/content/10.1101/534370.点此复制
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