Inhibiting BCKDK in triple negative breast cancer suppress protein translation, impair mitochondrial function, and potentiate doxorubicin cytotoxicity
Mueller Neil 1Dao Khoi Thien 1Mercer Angella 1Duffley Luke 1Pulinilkunnil Thomas 1Hiani Yassine El 2Kienesberger Petra 1Biswas Dipsikha 1Slade Logan1
作者信息
- 1. Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Dalhousie Medicine New Brunswick
- 2. Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University
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Key words
Triple-negative breast cancer/branched-chain ketoacid dehydrogenase kinase/apoptosis/mitochondria/protein synthesis/chemosensitivity引用本文复制引用
Mueller Neil,Dao Khoi Thien,Mercer Angella,Duffley Luke,Pulinilkunnil Thomas,Hiani Yassine El,Kienesberger Petra,Biswas Dipsikha,Slade Logan.Inhibiting BCKDK in triple negative breast cancer suppress protein translation, impair mitochondrial function, and potentiate doxorubicin cytotoxicity[EB/OL].(2025-03-28)[2025-12-14].https://www.biorxiv.org/content/10.1101/2021.05.18.444634.学科分类
肿瘤学/生物化学/分子生物学
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