心肌窦房结细胞数学模型比较研究

Paper compared models establishing for studying the electrophysiological characters of rabbit sinoatrial node cells (SANC) in these years. Ion current is one of the most important factors that can reflect the electrophysiological characters of SA node. The synthetical expression of these factors rely on cell membrane voltage (Vm), change of Vm reflect the movement of ion currents. Therefore, all evaluated models reproduce control ion currents, electrophysiological parameters, action potential shapes and regional differences in order to sort out the advantage ones. We finally confirmed that Zhang et al. model is the best suited for experimental data due to it considering the reginoal differences of SANC; Maltsev et al. model is the most exhaustive one of discribing the intracellular calcium handling processes.