Menstrual cycle associated alteration of vastus lateralis motor unit function
Menstrual cycle associated alteration of vastus lateralis motor unit function
Abstract Estrogen and progesterone are the primary female sex hormones and have net excitatory and inhibitory effects, respectively, on neuronal function. Fluctuating concentrations across the menstrual cycle has led to several lines of research in relation to neuromuscular function, yet evidence from animal and cell culture models have yet to be demonstrated in human motor units (MU) coupled with quantification of circulating hormones. Intramuscular electromyography (iEMG) was applied to record MU potentials (MUP) and corresponding MUP trains (MUPT) from the vastus lateralis of eumenorrheic females during the early follicular, ovulation and mid luteal phases of the menstrual cycle, alongside assessments of neuromuscular performance. Multi-level regression models were applied to explore effects of time and of contraction level. Statistical significance was accepted as p<0.05. Knee extensor maximum voluntary contraction (MVC), jump power, force steadiness, and balance did not differ across the menstrual phases (all p>0.4). Firing rate of low threshold MU (10% MVC) was reduced during phases of high progesterone (β=-0.82Hz, p<0.001), with no difference in MUPs analysed from 25% MVC contractions. MUPs were more complex during ovulation and mid luteal phase (p<0.03), with no change in neuromuscular junction transmission instability (p>0.3). Assessments of neuromuscular performance did not differ across the menstrual cycle. The suppression of low threshold MU firing rate during periods of increased progesterone may suggest a potential inhibitory effect and an alteration of recruitment strategy, however this had no discernible effect on performance. These findings highlight contraction level dependent modulation of VL MU function over the eumenorrheic cycle.
Piasecki Jessica、Phillips Bethan E.、Atherton Philip J.、Stashuk Daniel W.、Jones Eleanor J.、Piasecki Mathew、Guo Yuxiao
Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement Research Centre, Nottingham Trent UniversityCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, School of Medicine, University of NottinghamCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, School of Medicine, University of NottinghamDepartment of Systems Design Engineering, University of WaterlooCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, School of Medicine, University of NottinghamCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, School of Medicine, University of NottinghamCentre of Metabolism, Ageing & Physiology (COMAP), MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham
基础医学生理学妇产科学
Menstrual CycleMotor UnitEstrogenProgesteroneelectromyography
Piasecki Jessica,Phillips Bethan E.,Atherton Philip J.,Stashuk Daniel W.,Jones Eleanor J.,Piasecki Mathew,Guo Yuxiao.Menstrual cycle associated alteration of vastus lateralis motor unit function[EB/OL].(2025-03-28)[2025-05-17].https://www.biorxiv.org/content/10.1101/2023.03.27.534396.点此复制
评论