糖皮质激素保护听力的研究进展
Hearing protection by glucocorticoids
糖皮质激素多年来被用于治疗耳聋并取得了较好的疗效。动物实验表明糖皮质激素保护听力是通过糖皮质激素受体介导的,热压力(heat stress)、束缚压力(restraint stress)、噪声习服(sound conditioning)等也可以引起糖皮质激素水平的提高从而保护听力。受糖皮质激素受体调控的NF-кB、PLZF等可能在这一过程中发挥了重要作用。对糖皮质激素保护听力分子机制的进一步研究将对临床上治疗耳聋提供更多帮助。
Glucocorticoids have been used to treat hearing loss for many years. The hearing protection by glucocorticoids is mediated by glucocorticoid receptor, and heat stress, restraint stress, sound conditioning could increase blood glucocorticoids level and protect hearing. NF-кB、PLZF, et al. may play important roles in this process. More knowledge about the molecular mechanism of hearing protection by glucocorticoids will help us to provide better treatment for hearing loss.
王燕飞、徐志刚、刘月月
耳鼻咽喉科学基础医学
神经生物学耳聋糖皮质激素
Neurobiologyhearing lossglucocorticoids
王燕飞,徐志刚,刘月月.糖皮质激素保护听力的研究进展[EB/OL].(2013-11-01)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201311-27.点此复制
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