金属钯催化的中氮茚类化合物的合成

indolizines are considered to be an important heterocyclic compounds, which are common structural feature of numerous bioactive natural products and pharmaceutical molecules. palladium acetate catalyzed synthesis of indolizines via Pyridinium Ylides with terminal alkynes at ambient temperature in the presence of base. It provided a new and convenient method for the synthesis of such compounds. The method could get high yields and prepard easily for their materials，mild reaction conditions and simple operation.The selectivity of the substrates are more extensive. The synthesis of high yield 15 indolizine compounds, their structures was confirmed by NMR and MS.At the same time，the reaction mechanism has also been discussed and verified.