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首页|LONGITUDINAL OVARIAN RESERVE CHANGES IN WOMEN WITH BREAST CANCER RECEIVING ADJUVANT CHEMOTHERAPY OR TAMOXIFEN-ALONE

LONGITUDINAL OVARIAN RESERVE CHANGES IN WOMEN WITH BREAST CANCER RECEIVING ADJUVANT CHEMOTHERAPY OR TAMOXIFEN-ALONE

LONGITUDINAL OVARIAN RESERVE CHANGES IN WOMEN WITH BREAST CANCER RECEIVING ADJUVANT CHEMOTHERAPY OR TAMOXIFEN-ALONE

来源:medRxiv_logomedRxiv
英文摘要

ABSTRACT BackgroundTo determine the longitudinal impact of adjuvant chemotherapy and tamoxifen-only treatments on ovarian reserve by serum anti-Mullerian hormone (AMH) levels in women with breast cancer. MethodsOne-hundred-and-forty-two women with a primary diagnosis of breast cancer were prospectively followed with serum AMH assessments before the initiation, and 12, 18 and 24 months after the completion of adjuvant chemotherapy or the start of tamoxifen-only treatment. The chemotherapy regimens were classified into Anthracycline-Cyclophosphamide-based (AC-based) and Cyclophosphamide-Methotrexate+5-Fluorouracil (CMF). Longitudinal data were analyzed by mixed effects model for treatment effects over time, adjusting for baseline age and BMI. ResultsBoth chemotherapy regimens resulted in significant decline in ovarian reserve compared to the tamoxifen-only treatment (p<0.0001 either regimen vs. tamoxifen for overall trend). AMH levels sharply declined at 12 months but did not show a significant recovery from 12 to 18 and 18 to 24 months after the completion of AC-based or CMF regimens. The degree of decline did not differ between the two chemotherapy groups (p=0.53). In contrast, tamoxifen-only treatment did not significantly alter the age-adjusted serum AMH levels over the 24-month follow up. Likewise, the use of adjuvant tamoxifen following AC-based regimens did not affect AMH recovery. ConclusionsBoth AC-based and CMF regimens significantly compromise ovarian reserve, which does not recover during the 12-24-month post-chemotherapy follow up. In contrast, tamoxifen treatment does not seem to alter ovarian reserve. This novel information should be valuable for fertility preservation counselling and in assessing future reproductive potential of breast cancer survivors.

Bang Heejung、Goldfarb Shari B、Dickler Maura N、Turan Volkan、Bedoschi Giuliano、Taylan Enes、Abdo Nadia、Patil Sujita、Cigler Tessa、Oktay Kutluk H

Division of Biostatistics, Department of Public Health Sciences, University of CaliforniaMemorial Sloan Kettering Cancer Center||Weill Cornell Medical CenterMemorial Sloan Kettering Cancer CenterDepartment of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine||Department of Obstetrics and Gynecology, Health and Technology University School of MedicineDepartment of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine||Department of Obstetrics and Gynecology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao PretoDepartment of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of MedicineMemorial Sloan Kettering Cancer CenterMemorial Sloan Kettering Cancer CenterWeill Cornell Medical CenterDepartment of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine

10.1101/2020.06.21.20136689

肿瘤学妇产科学医学研究方法

Drug TherapyBreast NeoplasmsAnti-Mullerian HormoneFertility PreservationOvarian Reserve

Bang Heejung,Goldfarb Shari B,Dickler Maura N,Turan Volkan,Bedoschi Giuliano,Taylan Enes,Abdo Nadia,Patil Sujita,Cigler Tessa,Oktay Kutluk H.LONGITUDINAL OVARIAN RESERVE CHANGES IN WOMEN WITH BREAST CANCER RECEIVING ADJUVANT CHEMOTHERAPY OR TAMOXIFEN-ALONE[EB/OL].(2025-03-28)[2025-05-28].https://www.medrxiv.org/content/10.1101/2020.06.21.20136689.点此复制

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