Neutralizing antibodies against SARS-CoV-2 variants of concern elicited by the Comirnaty? COVID-19 vaccine in nursing home residents
Neutralizing antibodies against SARS-CoV-2 variants of concern elicited by the Comirnaty? COVID-19 vaccine in nursing home residents
ABSTRACT Immunosenescence may impact the functionality and breadth of vaccine-elicited humoral immune responses. The ability of sera to neutralize the SARS-CoV-2 spike protein (S) from Beta, Gamma, Delta, and Epsilon variants of concern (VOCs) relative to the ancestral Wuhan-Hu-1 strain was compared in Comirnaty? COVID-19-vaccinated elderly nursing home residents (n=30) or younger individuals (n=18) and non-vaccinated individuals who recovered from severe COVID-19 (n=19). In all groups, some participants lacked NtAb against one or more VOCs, mainly the Beta variant (15-20%). Serum NtAb titers were lowest against the Beta variant followed by Gamma, Epsilon, and Delta variants. Fold change reduction in NtAb titers relative to the ancestral strain was greatest for the Beta variant (6.7-18.8) followed by Gamma (3.6-6.2), Epsilon (2.9-5.8), and Delta (3.5-4.3) variants, regardless of the study group considered. In summary, older age, frailty, and concurrence of co-morbidities had no impact on the serum NtAb activity profile against SARS-CoV-2 VOCs.
Gim¨|nez Estela、S¨￠nchez-Sendra Beatriz、Botija Pilar、Rodado Celia、Geller Ron、Albert Eliseo、Torres Ignacio、Navarro David、Beltr¨￠n Mar¨aa Jos¨|、Zulaica Joao
Microbiology Service, Clinic University Hospital, INCLIVA Health Research InstituteInstitute for Integrative Systems Biology (I2SysBio), Universitat de Valencia-CSICDirecci¨?n de Atenci¨?n Primaria, Departamento de Salud Cl¨anico-Malvarrosa, Hospital Cl¨anico Universitario de ValenciaComisi¨?n Departamental de control de Residencias. Departamento de Salud Val¨¨ncia Cl¨anico MalvarrosaInstitute for Integrative Systems Biology (I2SysBio), Universitat de Valencia-CSICMicrobiology Service, Clinic University Hospital, INCLIVA Health Research InstituteMicrobiology Service, Clinic University Hospital, INCLIVA Health Research InstituteMicrobiology Service, Clinic University Hospital, INCLIVA Health Research Institute||Department of Microbiology, School of Medicine, University of ValenciaDirecci¨?n de Enfermer¨aa, Departamento de Salud Cl¨anico-Malvarrosa, Hospital Cl¨anico Universitario de ValenciaInstitute for Integrative Systems Biology (I2SysBio), Universitat de Valencia-CSIC
预防医学基础医学生物科学研究方法、生物科学研究技术
SARS-CoV-2 variantsNeutralizing antibodiesComirnaty? COVID-19 vaccineNursing home residents
Gim¨|nez Estela,S¨￠nchez-Sendra Beatriz,Botija Pilar,Rodado Celia,Geller Ron,Albert Eliseo,Torres Ignacio,Navarro David,Beltr¨￠n Mar¨aa Jos¨|,Zulaica Joao.Neutralizing antibodies against SARS-CoV-2 variants of concern elicited by the Comirnaty? COVID-19 vaccine in nursing home residents[EB/OL].(2025-03-28)[2025-05-28].https://www.medrxiv.org/content/10.1101/2021.10.06.21264607.点此复制
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