有氧运动对不同血糖水平男性人群动脉僵硬度的即时影响
Pulse wave velocity; Aerobic exercise; Fasting blood glucose; Arterial stiffness;Cardiovascular disease
目的 探究有氧运动对不同血糖水平人群动脉僵硬度的即时影响。方法 本研究以既参加开滦研究2018-2020年第6次随访体检又完成功率车二级负荷试验前后臂踝脉搏波传导速度(baPWV)测量者为研究对象。根据空腹血糖水平将观察对象按照四分位分组:Q1(n=220):<5.00 mmol/L、Q2(n=240):5.00~<5.40 mmol/L、Q3(n=230):5.40~<5.81 mmol/L、Q4(n=234):≥5.81 mmol/L。采用广义线性模型,分析不同血糖水平组功率车二级负荷试验前后baPWV的变化差异。结果 符合纳入标准的观察对象924人,年龄(36.93±7.72)岁。功率车二级负荷试验7min后即时测得的baPWV下降,较静息水平平均下降了36cm/s。校正相关混杂因素后,发现与空腹血糖水平最高四分位(Q4)组相比,空腹血糖水平最低四分位(Q1)组baPWV下降 18.96(95%CI -36.96,-0.96)cm/s。结论 有氧运动能即时改善动脉僵硬的程度,但高血糖减弱了有氧运动改善动脉僵硬度的作用,而且这种不利的作用独立于体质量指数(body mass index,BMI)、高血压等传统心血管疾病危险因素。
Objective To investigate the immediate effect of aerobic exercise on arterial stiffness in people with different blood glucose levels. Methods Those who participated in the sixth follow-up physical examination of the Kailuan Study from 2018 to 2020 and completed the brache-ankle Pulse Wave Velocity (baPWV) measurement before and after the secondary load test of the power vehicle were included in this study. According to fasting blood glucose levels, the observed subjects were grouped into quartile: Q1 (n=220) : FBG <5.00mmol/L,Q2 (n=240) : 5.00mmol/L≤ FBG <5.40mmol/L,Q3 (n=230) : 5.40mmol/L≤ FBG <5.81mmol/L,Q4 (n=234) : 5.81mmol/L≤ FBG .A generalized linear model was used to analyze the changes of baPWV before and after the secondary load test of power vehicle with different blood glucose levels. Results A total of 924 subjects met the inclusion criteria [age (36.93±7.72) years]. The baPWV measured immediately after 7 minutes of power vehicle secondary load test decreased by an average of 36cm/s from the resting level. After adjusting for confounding factors, baPWV decreased by 18.96[95%CI-36.96,-0.96]cm/smore in the group with the lowest fasting glucose (Q1) than in the group with the highest fasting glucose (Q4). Conclusion Aerobic exercise can immediately improve the degree of arterial stiffness, but hyperglycemia attenuates the effect of aerobic exercise. This adverse effect was independent of traditional cardiovascular risk factors such as BMI and hypertension.
臧懿然、张国、张丽、李鹏、张晓玲、吴寿岭、孙丽霞、何荣
医药卫生理论预防医学基础医学
脉搏波传导速度有氧运动血糖动脉僵硬度心血管疾病
臧懿然,张国,张丽,李鹏,张晓玲,吴寿岭,孙丽霞,何荣.有氧运动对不同血糖水平男性人群动脉僵硬度的即时影响[EB/OL].(2023-01-28)[2025-08-18].https://chinaxiv.org/abs/202301.00184.点此复制
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