Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant
Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant
Abstract The mutation profile of the SARS-CoV-2 Omicron variant poses a concern for naturally acquired and vaccine-induced immunity. We investigated the ability of prior infection with an early SARS-CoV-2, 99.99% identical to Wuhan-Hu-1, to protect against disease caused by the Omicron variant. We established that infection with Omicron in na?ve Syrian hamsters resulted in a less severe disease than a comparable dose of prototype SARS-CoV-2 (Australia/VIC01/2020), with fewer clinical signs and less weight loss. We present data to show that these clinical observations were almost absent in convalescent hamsters challenged with the same dose of Omicron 50 days after an initial infection with Australia/VIC01/2020. The data provide evidence for immunity raised against prototype SARS-CoV-2 being protective against Omicron in the Syrian hamster model. Further investigation is required to conclusively determine whether Omicron is less pathogenic in Syrian hamsters and whether this is predictive of pathogenicity in humans.
Fell Rachel、Fotheringham Susan A.、Summers Sian、Thomas Stephen R.、Wiblin Nathan R.、Vipond Richard、Bewley Kevin R.、Cavell Breeze E.、Emery Kirsty、Gooch Karen E.、Gowan Kathryn、Harris Debbie J.、Humphreys Richard、Johnson Rachel、Knott Daniel、Paterson Jemma、Watson Robert J.、Richards Kevin S.、Morley Daniel、Pullan Steven T.、Hall Yper、Osman Karen L.、Penn Elizabeth J.、Shaik Imam、Funnell Simon G. P.、Lister Sian、Carnell Oliver、Handley Alastair、Burton Christopher、Ryan Kathryn A.、Weldon Thomas、Coombes Naomi S.、Challis Amy、Hallis Bassam、Ngabo Didier
医学研究方法基础医学微生物学
SARS-CoV-2Omicron variantSyrian hamsteranimal modelcoronavirus
Fell Rachel,Fotheringham Susan A.,Summers Sian,Thomas Stephen R.,Wiblin Nathan R.,Vipond Richard,Bewley Kevin R.,Cavell Breeze E.,Emery Kirsty,Gooch Karen E.,Gowan Kathryn,Harris Debbie J.,Humphreys Richard,Johnson Rachel,Knott Daniel,Paterson Jemma,Watson Robert J.,Richards Kevin S.,Morley Daniel,Pullan Steven T.,Hall Yper,Osman Karen L.,Penn Elizabeth J.,Shaik Imam,Funnell Simon G. P.,Lister Sian,Carnell Oliver,Handley Alastair,Burton Christopher,Ryan Kathryn A.,Weldon Thomas,Coombes Naomi S.,Challis Amy,Hallis Bassam,Ngabo Didier.Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant[EB/OL].(2025-03-28)[2025-04-28].https://www.biorxiv.org/content/10.1101/2021.12.24.474081.点此复制
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