223Ra SPECT/CT模型显像探索研究

Background] 223Ra SPECT/CT imaging was essential for evaluating the efficacy of bone metastasis therapy in metastatic castration-resistant prostate cancer (mCRPC). [Purpose] To explore the parameters of the Carlson model, the PET/CT model and Hoffman 3D brain model 223Ra SPECT/CT imaging. [Methods] In this study, GE NM/CT 670 ES quality control tests were performed on the Carlson model, the PET/CT model, and the Hoffman 3D brain model, and quality control standard images were acquired from the three models, and then 223Ra SPECT/CT imaging was examined for all three models, and the acquired images were compared with the quality control standard images. [Results] The results of the study showed that 223Ra SPECT/CT was capable of tomographic imaging. The 223Ra SPECT/CT images from the Carlson model with hot-area resolution (22.3 mm) and cold-area resolution (22.3 mm) were fair in linearity and homogeneity. The 223Ra SPECT/CT images from the PET/CT model were fair, whereas fusion matching degree and attenuation correction dispersion indexes of transverse, coronal, and sagittal images were a certain gap from the 99mTc SPECT/CT quality control images. The 223Ra SPECT/CT images in the Hoffman brain model showed that the intracerebral sulcus gyrus and basal ganglia nuclei were not clearly displayed, and it is necessary to continue to improve the image quality. [Conclusions] The study showed that the 223Ra SPECT/CT images were acceptable, which proved that the 223Ra SPECT/CT could be used to visualize clinical patients, but in order to obtain better quality images, the specific conditions of the visualization parameters need to be further explored.