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三草降压汤有效组分对成年自发性高血压大鼠宏观表征和行为学指标的影响

Influences on the macroscopic token and behavior in SHR of the components of Sancao Jiangya Decoction

中文摘要英文摘要

目的:探讨中药降压复方的综合疗效。方法:建立自发性高血压大鼠模型宏观表征和行为学指标的观察和测定方法,以正常Wistar 大鼠为对照,分别观察了三草降压汤有效组分(SCD-95ET) 和化学降压药硝苯地平在降低原发性高血压大鼠(SHR) 血压的同时,对其宏观表征和行为学的影响。结果: SCD-95ET和硝苯地平对SHR 宏观表征和行为学指标的影响表现出不同的特点,SCD-95ET对自发性高血压的食量、小便量、旋转时间、站立次数等指标均有较大影响。结论:中药复方与化学药物对高血压的整体治疗效果有所差异,根据中医辨证用药的特点,建立适合中药降压复方疗效评价的方法与标准,是推动中药降压新药研究的关键之一。

In this paper to evaluate the antihypertensive efficacy of Sancao decoction compound. we had build up the Methods: The spontaneously hypertensive rat model of macro-characterization and observation of behavioral indicators and measurement methods, normal Wistar rats as control, were observed three grass buck soup components (SCD-95ET) and chemical buck drug nifedipine in lowering blood pressure in hypertensive rats (SHR), while the impact of macro characterization and behavior of school. Results: SCD-95ET and nifedipine SHR macro characterization and behavioral indices showed different characteristics, SCD-95ET spontaneously hypertensive appetite, urine volume, rotation time, standing Views indicators have larger impact. Conclusion: Chinese herbal compound with chemical drugs differ from the overall treatment effect of the high blood pressure, according to the characteristics of TCM syndrome medication, establish methods and standards for traditional Chinese medicine antihypertensive compound efficacy evaluation, is one of the keys to promote traditional Chinese medicine antihypertensive drug research..

王雪茜、王冬、王庆国、赵伟鹏

医药卫生理论中医学基础医学

中药实验药理学三草降压汤有效组分自发性高血压大鼠宏观表征和行为学。

raditional Chinese Medicine Experimental Pharmacologycomponents of Sancao Jiangya DecoctionSHRmacroscopic token and behavior

王雪茜,王冬,王庆国,赵伟鹏.三草降压汤有效组分对成年自发性高血压大鼠宏观表征和行为学指标的影响[EB/OL].(2013-03-12)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201303-416.点此复制

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