基于生物信息学的lncRNA研究现状与发展趋势

Long non-coding RNAs (lncRNAs) are a class of non-coding transcripts longer than 200 nucleotides. Recently, many studies have shown that lncRNAs were involved in a wide variety of physiological and pathological processes of the organism, especially play important roles in the development of cancer. In this review, we discussed the current bioinformatics progress of lncRNA both at home and abroad, including four popular parts: prediction of lncRNA sequences, sequence feature analysis and structure prediction, function annotation and prediction, roles in cancer development. We hope this review will provide a reference for further in-depth study of lncRNA.