探讨补肾通腑法对血管性痴呆大鼠抗炎作用和SIRT1/NF-κBP65信号通路的影响
Explore the effect of of Tonifying kidney and Free the bowels method on anti inflammation and SIRT1/NF- kappa BP65 signaling pathway in vascular dementia rats
血管性痴呆（vascular dementia VD）是老年痴呆的第2大病因，也是目前唯一可以防治的痴呆类型，研究发现，脑缺血病变后炎症反应是脑组织损伤的一个机制重要机制，从炎症通路的角度开辟新的防治原则成为一个研究热点。中医医家认为肾精亏虚是VD的主要病机，腑气不通是其症候要素，临床上补肾通腑法辩证运用于VD具有明确的思路，探讨补肾通腑代表方而二至丸是否作用于抗炎通路SIRT1/NF-κBP65从而起到防治作用，为临床提供新的思路和治疗原则。
vascular dementia (VD) in the second major causes of dementia, is currently the only prevention of dementia, the study found that the inflammatory reaction after cerebral ischemia is an important mechanism of brain tissue injury, from inflammatory pathway opens a new angle control principle has become a research hotspot.Chinese doctors think that kidney deficiency is the main pathogenesis of VD, Fu Qi is the syndrome factors, clinical kidney Tongfu dialectical used in VD has clear ideas, to study the effect of Tongfu on behalf of two is applied to pill anti-inflammatory pathway SIRT1/NF- kappa BP65 so as to provide ideas and treatment of prevention and cure effect. NEW principles for clinical.
丁笑、赵书亚、陈俊炜、黄家望、曾丽红、易亚乔
中医学神经病学、精神病学基础医学
补肾通腑法血管性痴呆抗炎作用SIRT1/NF-κB
onifying kidney and Free the bowels methodvascular dementiaanti-inflammatory effectSIRT1
丁笑,赵书亚,陈俊炜,黄家望,曾丽红,易亚乔.探讨补肾通腑法对血管性痴呆大鼠抗炎作用和SIRT1/NF-κBP65信号通路的影响[EB/OL].(2017-11-03)[2025-08-23].http://www.paper.edu.cn/releasepaper/content/201711-7.点此复制
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