氯化琥珀胆碱对大鼠脑基底动脉收缩和舒张功能的影响
Effet of succinylcholine chloride on vasoconstriction and vasodilatation of cerebral basilar artery in rats
目的: 研究氯化琥珀胆碱(Suc)对大鼠脑基底动脉收缩和舒张功能的影响。方法:用血管直径测定法分别测定KCl诱导的大鼠脑基底动脉(CBA)的收缩和乙酰胆碱(ACh)诱导的舒张反应。结果: 500 ng/mL Suc可明显地减弱KCL诱导的大鼠CBA收缩，并可明显减弱ACh诱导的舒张反应，使最大舒张反应从PSS对照组的110.2 ± 4.0%降低到68.5 ± 16.7%。结论：Suc对大鼠脑基底动脉的收缩和舒张功能有直接的抑制作用，其抑制血管舒张功能可能与血管内皮细胞损伤有关。?????
Objective: to study the effect of succinylcholine chloride (Suc) on vasoconstriction and vasodilatation of cerebral basilar artery (CBA) in rat. Methods: KCl-induceand vasoconstriction and acetylcholine (ACh)-vasodilation were measured by vascular diameter assay. Results: 500 ng/mL Suc could significantly weaken the contraction of CBA induced by KCL; Suc also markedly inhibited the ACh-induced relaxation response, the maximum relaxation response decreased from 110.2 ± 4.0% in the PSS control group to 68.5 ±16.7%. Conclusion: Suc could directly inhibit the vasoconstriction and relaxation of rat CBA, and its inhibition on vasodilation may be related to injury of vascular endothelial cells.?????
文继月、郭岩、陈志武、刘欣
基础医学生理学
氯化琥珀胆碱大鼠脑基底动脉收缩舒张?????
Succinylcholine chlorideRatCerebral basilar arteryContractionRelaxation?????
文继月,郭岩,陈志武,刘欣.氯化琥珀胆碱对大鼠脑基底动脉收缩和舒张功能的影响[EB/OL].(2019-12-19)[2025-08-10].http://www.paper.edu.cn/releasepaper/content/201912-73.点此复制
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