血红素加氧酶-1的非酶活性研究进展

IHeme oxygenase-1 (HO-1) is a microsomal oxygenase responsible for the catabolism of heme from destabilized heme proteins. For its potent anti-oxidant properties, HO-1 is regarded as a key cellular 20 defense mechanism. Recently, the effects of HO-1 independent of its enzyme activity have been identified. HO-1 is able to be transported from endoplasmic reticulum to the nucleus. After nuclear transportation, HO-1 regulates transcription of target genes responsible for redox oxidation, inflammation, interferon function and oncogenesis, and participates in DNA repairment and self-regulation. Thus, the enzyme activity-independent effect of HO-1 might play a critical role in the 25 pathogenesis of several diseases. The present article will review the current studies regarding the enzyme activity-independent effect of HO-1.