基于流式细胞仪分析超声造影剂包膜特性的实验研究
Microbubble Shell Characterization Using Flow Cytometry
本文采用进过改进的流式细胞仪测量了单个Definity?超声造影剂微泡的动力学行为，并对其包膜特性（剪切模量及剪切粘度）进行了分析。通过对实验测量得到的微泡动力学响应数据进行气泡动力学拟合来可以确定不同驱动声压下造影剂微泡的包膜特性。结果显示：造影剂微泡包膜的剪切粘度随微泡平衡半径的增大而增大，随剪切速率的增大而减小；而包膜的弹性系数不随微泡的大小而变化。
Experiments were performed to evaluate the shell parameters for individual Definity?ultrasound contrast microbubbles using a modified flow cytometer. The shell parameters (shear modulus and shear viscosity) were quantified at different acoustic pressures by fitting microbubble response data to a bubble dynamics model. The results show that: (1) the shell shear viscosity increases with increasing equilibrium microbubble size, and decreases with increasing shear rate; (2)the shell elasticity does not vary with microbubble size.
陈伟中、屠娟
医学研究方法生物科学研究方法、生物科学研究技术声学工程
超声造影剂流式细胞仪气泡动力学包膜特性
Ultrasound Contrast AgentsFlow CytometeryBubble DynamicsShell Properties
陈伟中,屠娟.基于流式细胞仪分析超声造影剂包膜特性的实验研究[EB/OL].(2011-01-11)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201101-474.点此复制
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