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High seroprevalence of SARS-CoV-2 antibodies among people living in precarious situations in Ile de France

High seroprevalence of SARS-CoV-2 antibodies among people living in precarious situations in Ile de France

来源:medRxiv_logomedRxiv
英文摘要

Abstract BackgroundA nationwide lockdown was implemented in France on 17 March 2020 to control the COVID-19 pandemic. People living in precarious conditions were relocated by the authorities to emergency shelters, hotels and large venues. Médecins sans Frontières (MSF) then intervened to provide medical care in several of these locations in Paris and in Seine-Saint-Denis, one of its suburbs, between March and June 2020. A seroprevalence survey was conducted to assess the level of exposure to COVID-19 among the population living in the sites. To our knowledge, this is the first assessment of the impact of the pandemic on populations living in insecure conditions in Europe. MethodsWe conducted a cross-sectional seroprevalence study in the food distribution sites, emergency shelters and workers residences supported by MSF in Paris and Seine-Saint-Denis, to determine the extent of COVID-19 exposure as determined by SARS-CoV2 antibody seropositivity. The detection of SARS-COV2 antibodies in serum was performed at the Institut Pasteur of Paris using two LuLISA (Luciferase-Linked Immunosorbent Assay) assays and a Pseudo Neutralization Test. A questionnaire covering sociodemographic characteristics, living conditions, adherence to sanitary recommendations and symptom manifestations was also completed. We describe here the seroprevalence site by site and identify the risk factors for seropositivity using a multivariable logistic regression model with site random effects. We also investigated associations between seropositivity and symptoms eventually reported. FindingsOverall, 426/818 individuals tested positive in the 14 sites investigated. Seroprevalence varied significantly with the type of site (chi2 p<0.001). It was highest at 88.7% (95%CI 81.8-93.2) among individuals living in workers’ residences, followed by 50.5% (95%CI 46.3-54.7) in emergency shelters and 27.8 % (95%CI 20.8-35.7) among individuals recruited from the food distribution sites. Seroprevalence also varied significantly between sites of the same type. Among other risk factors, the odds for seropositivity were higher among individuals living in crowded sites (medium: adj. OR 2.7, 95%CI 1.5-5.1, p=0.001; high: adj. OR 3.4, 95%CI 1.7-6.9, p<0.001) compared with individuals from low crowding sites and among those who reported transit accommodation in a gymnasium before the lockdown (adj. OR 3.1, 95%CI 1.2-8.1, p=0.023). More than two-thirds of the seropositive individuals (68.3%; 95%CI 64.2-72.2) did not report any symptoms during the recall period. InterpretationThe results demonstrate rather high exposure to SARS-COV-2 with important variations between study sites. Living in crowded conditions was identified as the most important explanatory factor for differences in levels of exposure. This study describes the key factors which determine the risk of exposure and illustrates the importance of identifying populations at high risk of exposure in order to orient and adapt prevention and control strategies to their specific needs.

Rose Thierry、Simons Erica、Vincent Charline、Llosa Augusto、Vanhomwegen Jessica、Anna Fran?ois、Fourrey Emilie、Coury Anneliese、Vanel Stefan、Mills Clair、Vratskikh Oxana、Hennequin William、Goyard Sophie、Porten Klaudia、Nikolay Birgit、Mendiharat Pierre、Mollo Bastien、Luquero Francisco、Roederer Thomas、Nesbitt Robin、Torre Corinne、Janin Yves、Charneau Pierre

Unit of Lymphocyte Cell Biology, Immunology Department, Institut PasteurEpicentre, ParisM¨|decins Sans Fronti¨¨resEpicentre, ParisEnvironment and Infectious Risks Research and Expertise Unit, Global Health Department, Institut PasteurUnit of Molecular Virology and Vaccinology, Virology Department, Institut Pasteur||Theravectys, ParisM¨|decins Sans Fronti¨¨resM¨|decins Sans Fronti¨¨resM¨|decins Sans Fronti¨¨resM¨|decins Sans Fronti¨¨resEnvironment and Infectious Risks Research and Expertise Unit, Global Health Department, Institut PasteurM¨|decins Sans Fronti¨¨resUnit of Lymphocyte Cell Biology, Immunology Department, Institut PasteurEpicentre, ParisEpicentre, ParisM¨|decins Sans Fronti¨¨resM¨|decins Sans Fronti¨¨resEpicentre, ParisEpicentre, ParisEpicentre, ParisM¨|decins Sans Fronti¨¨resUnit of Chemistry and Biocatalysis, Institut Pasteur, UMR 3523 CNRSUnit of Molecular Virology and Vaccinology, Virology Department, Institut Pasteur||Theravectys, Paris

10.1101/2020.10.07.20207795

医学研究方法预防医学医药卫生理论

SARS-CoV-2COVID-19SeroprevalenceEpidemiological surveyAntibodiesHomelessPrecariousLuLISAIle-de-FranceFrance

Rose Thierry,Simons Erica,Vincent Charline,Llosa Augusto,Vanhomwegen Jessica,Anna Fran?ois,Fourrey Emilie,Coury Anneliese,Vanel Stefan,Mills Clair,Vratskikh Oxana,Hennequin William,Goyard Sophie,Porten Klaudia,Nikolay Birgit,Mendiharat Pierre,Mollo Bastien,Luquero Francisco,Roederer Thomas,Nesbitt Robin,Torre Corinne,Janin Yves,Charneau Pierre.High seroprevalence of SARS-CoV-2 antibodies among people living in precarious situations in Ile de France[EB/OL].(2025-03-28)[2025-05-17].https://www.medrxiv.org/content/10.1101/2020.10.07.20207795.点此复制

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