Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients
Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients
SUMMARY While SARS-CoV-2 mRNA vaccination has been shown to be safe and effective in the general population, immunocompromised solid organ transplant recipients (SOTR) were reported to have impaired immune responses after one or two doses of vaccine. In this study, we examined humoral responses induced after the second and the third dose of mRNA vaccine in different SOTR (kidney, liver, lung and heart). Compared to a cohort of SARS-CoV-2 na?ve immunocompetent health care workers (HCW), the second dose induced weak humoral responses in SOTR, except for the liver recipients. The third dose boosted these responses but they did not reach the same level as in HCW. Interestingly, while the neutralizing activity against Delta and Omicron variants remained very low after the third dose, Fc-mediated effector functions in SOTR reached similar levels as in the HCW cohort. Whether these responses will suffice to protect SOTR from severe outcome remains to be determined.
Finzi Andr¨|s、Cloutier Marc、H¨|bert Marie-Jos¨|e、Tauzin Alexandra、Beaudoin-Bussi¨¨res Guillaume、Gong Shang Yu、Tremblay C¨|cile、Duerr Ralf、Gendron-Lepage Gabrielle、Turgeon Julie、Khrifi Zineb、Dieud¨| M¨|lanie、Martel-Laferri¨¨re Val¨|rie、Chatterjee Debashree、Racine Normand、Goyette Guillaume、Kaufmann Daniel E.、Bourassa Catherine、Bazin Ren¨|e
Centre de Recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|al||Department of Microbiology and Immunology, McGill UniversityH¨|ma-Qu¨|bec, Affaires M¨|dicales et InnovationCentre de Recherche du CHUM||Canadian Donation and Transplantation Research Program (CDTRP)||D¨|partement de M¨|decine, Universit¨| de Montr¨|alCentre de Recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|alCentre de Recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|alCentre de Recherche du CHUM||Department of Microbiology and Immunology, McGill UniversityCentre de Recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|alDepartment of Microbiology, New York University School of MedicineCentre de Recherche du CHUMCentre de Recherche du CHUM||Canadian Donation and Transplantation Research Program (CDTRP)Centre de Recherche du CHUMCentre de Recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|al||Canadian Donation and Transplantation Research Program (CDTRP)Centre de Recherche du CHUM||D¨|partement de Microbiologie, Infectiologie et Immunologie, Universit¨| de Montr¨|alCentre de Recherche du CHUMInstitut Cardiologie de Montr¨|alCentre de Recherche du CHUMCentre de Recherche du CHUM||D¨|partement de M¨|decine, Universit¨| de Montr¨|alCentre de Recherche du CHUMH¨|ma-Qu¨|bec, Affaires M¨|dicales et Innovation
医药卫生理论医学研究方法预防医学
Solid organ transplant recipientsVaccinationCoronavirusCOVID-19SARS-CoV-2Spike glycoproteinsHumoral responsesNeutralizationADCCVariants of concern
Finzi Andr¨|s,Cloutier Marc,H¨|bert Marie-Jos¨|e,Tauzin Alexandra,Beaudoin-Bussi¨¨res Guillaume,Gong Shang Yu,Tremblay C¨|cile,Duerr Ralf,Gendron-Lepage Gabrielle,Turgeon Julie,Khrifi Zineb,Dieud¨| M¨|lanie,Martel-Laferri¨¨re Val¨|rie,Chatterjee Debashree,Racine Normand,Goyette Guillaume,Kaufmann Daniel E.,Bourassa Catherine,Bazin Ren¨|e.Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients[EB/OL].(2025-03-28)[2025-05-02].https://www.medrxiv.org/content/10.1101/2022.05.13.22275056.点此复制
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