肾素轴抑制对心房颤动重构的研究进展

trial fibrillation (AF) is one of the common arrhythmia which is closely related to the age of the patients. The risk of stroke in patients with AF is also increased. Study on mechanisms of AF. Atrial remodeling include includes atrial electrical remodeling and atrial structural remodeling, which are the material basis for the development of atrial remodeling. The activation of the renin angiotensin aldosterone system (RAAS) plays an important role in this process. Clinical trials proved that angiotensin angiotensin converting enzyme inhibitor (ACEI) and vascular tension endothelin receptor antagonist (ARB) can reduce the incidence of AF and reduce the recurrence of AF, especially in patients with poor cardiac function in patients. In animal models, the study of aldosterone antagonists provides a promising prospect for the breakthrough of the treatment of AF. Novel renin inhibitor aliskiren can block RAAS system fundamentally, may have an obvious effect of atrial remodeling.