Altered Neurotransmitter Ratio in the Prefrontal Cortex is Associated with Pain in Fibromyalgia Syndrome
Altered Neurotransmitter Ratio in the Prefrontal Cortex is Associated with Pain in Fibromyalgia Syndrome
ABSTRACT The central mechanisms underlying fibromyalgia syndrome (FMS) remain undetermined. The dorsolateral prefrontal cortex (DLPFC) is particularly relevant to FMS because it is implicated in cognitive, affective, and top-down pain regulation. Imbalances in excitatory (Glutamate) and inhibitory (Gamma aminobutyric acid; GABA) neurochemicals may play a critical role in the pathophysiology of the condition and more generally in homeostatic function within cortical circuits. Although the balance of excitation and inhibition are intrinsically linked no investigations to date have investigated the E/I ratio in FMS. Thus, the primary objective of this study was to determine whether the E/I ratio in the DLPFC is altered in participants with FMS compared to healthy controls using magnetic resonance spectroscopy. Additionally, we examined the relationship between E/I ratio and pain metrics. We hypothesized that the E/I ratio within the DLPFC would be altered in participants with FMS compared to controls and, secondly, that E/I ratio would be associated with both clinical pain and thermal pain sensitivity. The Brief Pain Inventory (BPI) self-assessment was used to evaluate pain severity and impact on physical functioning and acute pain sensitivity was determined via quantitative sensory testing to define thermal (heat) pain threshold and tolerance. Our results revealed an elevation in the E/I ratio in FMS compared to controls. A positive relationship between E/I ratio and thermal pain sensitivity measures was identified in the FMS cohort. Collapsing across groups, there was a positive relationship between E/I ratio and BPI score. These findings suggest that dysfunction in the balance between excitation and inhibition within cognitive brain circuitry may play a role in pain processing in FMS.
Sacchet Matthew D.、Spiegel David、Williams Nolan、Geoly Andrew、Khan Naushaba、Maron-Katz Adi、Azeez Azeezat、Tischler Claudia、Amin Heer、Gu Meng、Faerman Afik、Baltusis Laima、Spielman Daniel、Yeomans David C.、Hurd Ralph、Bishop James H.
Meditation Research Group, Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical SchoolDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, Stanford University||Sierra Pacific Mental Illness Research Education and Clinical Centers, VA Palo Alto Health Care SystemDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityDepartment of Radiology, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityCenter for Cognitive and Neurobiological Imaging, Stanford UniversityDepartment of Radiology, Stanford UniversityDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford UniversityDepartment of Radiology, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, Stanford University||Department of Radiology, Stanford University
神经病学、精神病学基础医学医学研究方法
FibromyalgiaMRSDLPFCThermal PainGlx/GABA
Sacchet Matthew D.,Spiegel David,Williams Nolan,Geoly Andrew,Khan Naushaba,Maron-Katz Adi,Azeez Azeezat,Tischler Claudia,Amin Heer,Gu Meng,Faerman Afik,Baltusis Laima,Spielman Daniel,Yeomans David C.,Hurd Ralph,Bishop James H..Altered Neurotransmitter Ratio in the Prefrontal Cortex is Associated with Pain in Fibromyalgia Syndrome[EB/OL].(2025-03-28)[2025-05-07].https://www.medrxiv.org/content/10.1101/2021.10.28.21265618.点此复制
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