血清IL-6水平与儿童肥胖、非酒精性脂肪肝的关系研究
he study on relationship between serum IL-6 level and obesity or nonalcoholic fatty liver disease in children.
目的 研究血清白细胞介素-6（IL-6）水平在非酒精性脂肪肝（NAFLD）、肥胖儿童中的变化。方法 采用双抗体夹心酶联免疫吸附法（ELISA）测定了217名儿童血清IL-6水平，包括体重正常者77例，肥胖者140例；66例NAFLD患儿（其中轻度49例，中重度17例）及151例非NAFLD儿童。结果 体重正常组与肥胖组IL-6水平无差异（p>0.05）。NAFLD组的IL-6水平明显高于非NALFD组（p<0.01）。轻度NAFLD组IL-6水平高于非NAFLD组（p<0.05），中重度NAFLD组也高于非NAFLD组，但差异无显著性意义（p>0.05）。结论 IL-6与NAFLD有关，可能在儿童脂肪肝的发病过程中起一定作用。
Objective: To study the relationship between serum IL-6 level and obesity or NAFLD in children. Methods: A total of 217 children, including 77 normal-weight and 140 obese children; 66 NAFLD (49 mild, 17 moderate or severe) and 151 non-NAFLD children. Results: No difference was found for serum IL-6 level between obese and normal-weight children(p>0.05). Children with NAFLD had a significantly higher serum IL-6 than non-NAFLD subjects(p<0.01). Mild NAFLD children had higher serum IL-6 than non-NAFLD subjects(p<0.05), while moderate or severe NAFLD had also higher serum IL-6 than non-NAFLD subjects without statistical significance(p>0.05). Conclusion: We found serum IL-6 level was associated with NAFLD, indicating elevated level of IL-6 may contribute to the pathogenesis of NAFLD.
董彬、马军、王海俊、裴正存
儿科学基础医学
肥胖非酒精性脂肪肝白细胞介素-6儿童
obesityNAFLDIL-6children
董彬,马军,王海俊,裴正存.血清IL-6水平与儿童肥胖、非酒精性脂肪肝的关系研究[EB/OL].(2011-01-24)[2025-08-23].http://www.paper.edu.cn/releasepaper/content/201101-1134.点此复制
评论