富勒烯及其衍生物对卵母细胞的作用

Fullerene is one form of carbon allotropes. With the fast development of preparation methods of water soluble fullerene and its derivatives, the biological effects of fullerene and its derivatives have been widely studied. Here we report the studies of the effect of fullerene on mouse oocytes under irradiation. The results indicate fullerene-PVP solution and fullerenols have no obvious effect on oocyte in vitro maturation; but 2P, a water-soluble phosphonic acid derivative of fullerene, inhibits oocytes maturation and parthenogenetic activation. The effect of 2P was dose-dependent.