Kinetics and seroprevalence of SARS-CoV-2 antibodies – a comparison of 3 different assays
Kinetics and seroprevalence of SARS-CoV-2 antibodies – a comparison of 3 different assays
Abstract PurposeComparing seroprevalence and antibody kinetics in three different commercially available assays for SARS-CoV-2. MethodsSerostatus of COVID-19 patients was analyzed 5 months and 10 months after their infection, using three different assays: Diasorin LIAISON?, Euroimmun?, Abbott Diagnostics? ARCHITECT. ResultsSeropositivity at baseline differed significantly depending on the assay (Diasorin 81%, Euroimmun 83%, Abbott 59%). At follow-up antibody levels detected in the Diasorin assay were stable, while there was a significant loss in seropositivity in the Euroimmun and Abbott assays. ConclusionThere are significant differences in SARS-CoV-2 antibody kinetics based on the specific assay used. Trial registration number, date of registrationDRKS00022549, 29.07.2020 “retrospectively registered”
Kahre Elisabeth、Unrath Manja、Haag Luise、Blankenburg Judith、Galow Lukas、Dalpke Alexander H.、Armann Jakob P.、L¨1ck Christian、Berner Reinhard
Department of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universit?t DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universit?t DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universit?t DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universit?t DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universit?t DresdenInstitute for Medical Microbiology and Virology, Medical Faculty Carl Gustav Carus, Technische Universit?t DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universit?t DresdenInstitute for Medical Microbiology and Virology, Medical Faculty Carl Gustav Carus, Technische Universit?t DresdenDepartment of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universit?t Dresden
医学研究方法基础医学
seroprevalenceantibodiesSARS-CoV-2assaycomparison
Kahre Elisabeth,Unrath Manja,Haag Luise,Blankenburg Judith,Galow Lukas,Dalpke Alexander H.,Armann Jakob P.,L¨1ck Christian,Berner Reinhard.Kinetics and seroprevalence of SARS-CoV-2 antibodies – a comparison of 3 different assays[EB/OL].(2025-03-28)[2025-04-29].https://www.medrxiv.org/content/10.1101/2021.03.10.21253273.点此复制
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