PLGA微球小分子药物释放系统的构筑与性能研究

With the rapid growth of microspheres in the field of biotechnology and biomaterials, the microspheres technology provided a new ideas and methods for small molecule drug delivery system. In this work, biodegradable poly（lactic-co-glycolic acid）（PLGA）was used a carrier, fluorescein isothiocyanate (FITC) as the model drug and the PLGA microspheres containing FITC were fabricated by using a double emulsion method. The scanning electron microscope (SEM), fluorescence microscopy, transmission electron microscopy (TEM), laser diffraction size analyzer and UV-Spectroscopy were then applied to characterize the morphology, structure, particle size distribution and mean diameter of the resulting PLGA microspheres. The results indicated that the microspheres exhibited well-controlled core-shell structure, uniform size distribution, high drug loading and drug encapsulation efficiency, which make it an effective cwrrier for growth factors delivery in tissue engineering applications.