Assessment of Environmental Factors Associated with Antibiotic Resistance Genes (ARGs) in the Yangtze Delta, China
Assessment of Environmental Factors Associated with Antibiotic Resistance Genes (ARGs) in the Yangtze Delta, China
Abstract The emergence of antimicrobial resistance (AMR) is an urgent and complex public health challenge worldwide. As a sub-problem of AMR, antibacterial resistance (ABR) is of particular concern due to inadequacy of alternative medication. Earlier studies have shown that ABR is not only impacted by antibiotics, but also affected by the interactions between bacteria and their environments. Therefore, to combat ABR in a specific region, local environmental conditions must be investigated to comprehensively understand which environmental factors might contribute to ABR and propose more tailored solutions. This study surveyed environmental contributors of antibiotic resistance genes (ARGs), the parameter for measuring ABR, in the Yangtze Delta. A high abundance of ARGs was detected, despite low antibiotic and heavy metal concentrations. Phosphorus, chromium, manganese, calcium, and strontium were identified as potential key contributors of ARGs. Suppression of ARGs could be realized through decreasing the concentration of phosphorus in surface water. Group 2A light metals (e.g., magnesium and calcium) could be developed as eco-friendly reagents for controlling antibiotic resistance in the future.
Ling Yikai、Chen Xiaoyuan、Wu Siyuan、Xu Shixin、Anderson Benjamin D.、Miao Jiazheng、Umar Sajid
Division of Natural and Applied Science, Duke Kunshan UniversityDivision of Natural and Applied Science, Duke Kunshan UniversityDivision of Natural and Applied Science, Duke Kunshan UniversityDivision of Natural and Applied Science, Duke Kunshan University||Global Health Research Center, Duke Kunshan UniversityDivision of Natural and Applied Science, Duke Kunshan University||Global Health Research Center, Duke Kunshan University||Department of Environmental and Global Health, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of FloridaDivision of Natural and Applied Science, Duke Kunshan UniversityGlobal Health Research Center, Duke Kunshan University
环境科学技术现状环境生物学微生物学
antimicrobial resistanceantibiotic resistance genesantibiotic residuesdissolved metalsurface waterenvironmental health
Ling Yikai,Chen Xiaoyuan,Wu Siyuan,Xu Shixin,Anderson Benjamin D.,Miao Jiazheng,Umar Sajid.Assessment of Environmental Factors Associated with Antibiotic Resistance Genes (ARGs) in the Yangtze Delta, China[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2022.12.05.22283137.点此复制
评论