High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in healthcare workers: results of the CoV-CONTACT prospective cohort
High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in healthcare workers: results of the CoV-CONTACT prospective cohort
Abstract ObjectiveWe aimed to estimate the risk of infection in Healthcare workers (HCWs) following a high-risk exposure without personal protective equipment (PPE). MethodsWe conducted a prospective cohort in HCWs who had a high-risk exposure to SARS-CoV-2-infected subject without PPE. Daily symptoms were self-reported for 30 days, nasopharyngeal swabs for SARS-CoV-2 RT-PCR were performed at inclusion and at days 3, 5, 7 and 12, SARS-CoV-2 serology was assessed at inclusion and at day 30. Confirmed infection was defined by positive RT-PCR or seroconversion, and possible infection by one general and one specific symptom for two consecutive days. ResultsBetween February 5th and May 30th, 2020, 154 HCWs were enrolled within 14 days following one high-risk exposure to either a hospital patient (70/154; 46.1%) and/or a colleague (95/154; 62.5%). At day 30, 25.0% had a confirmed infection (37/148; 95%CI, 18.4%; 32.9%), and 43.9% (65/148; 95%CI, 35.9%; 52.3%) had a confirmed or possible infection. Factors independently associated with confirmed or possible SARS-CoV-2 infection were being a pharmacist or administrative assistant rather than being from medical staff (adjusted OR (aOR)=3.8, CI95%=1.3;11.2, p=0.01), and exposure to a SARS-CoV-2-infected patient rather than exposure to a SARS-CoV-2-infected colleague (aOR=2.6, CI95%=1.2;5.9, p=0.02). Among the 26 HCWs with a SARS-CoV-2-positive nasopharyngeal swab, 7 (26.9%) had no symptom at the time of the RT-PCR positivity. ConclusionsThe proportion of HCWs with confirmed or possible SARS-CoV-2 infection was high. There were less occurrences of high-risk exposure with patients than with colleagues, but those were associated with an increased risk of infection.
Burdet Charles、Manchon Pauline、Charpentier Charlotte、Guedj J¨|r¨|mie、Descamps Diane、Leclercq Anne、Attia Mika?l、Demeret Caroline、Goossens Herman、Duval Xavier、Tubiana Sarah、Behillil Sylvie、Thy Michael、Lucet Jean-Christophe、Rose Thierry、van der Werf Sylvie、Bielicki Julia Anna、Yazdanpanah Yazdan、Alavoine Loubna、Houhou Nadhira、Blanquart Fran?ois、Bruijning-Verhagen Patricia、Lina Bruno
AP-HP, H?pital Bichat, Centre d?ˉInvestigation Clinique||Universit¨| de Paris||AP-HP, H?pital Bichat, D¨|partement d?ˉEpid¨|miologie, Biostatistique et RechercheAP-HP, H?pital Bichat, Centre d?ˉInvestigation Clinique||AP-HP, H?pital Bichat, D¨|partement d?ˉEpid¨|miologie, Biostatistique et RechercheUniversit¨| de Paris||AP-HP, H?pital Bichat, Laboratoire de VirologieAP-HP, H?pital Bichat, Centre d?ˉInvestigation Clinique||Universit¨| de ParisUniversit¨| de Paris||AP-HP, H?pital Bichat, Laboratoire de VirologieAP-HP, Beaujon Hospital, Direction des soinsPhysique des fonctions biologiquesMolecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Universit¨| de Paris, Institut PasteurLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine and Health Science, University of AntwerpAP-HP, H?pital Bichat, Centre d?ˉInvestigation Clinique||Universit¨| de ParisAP-HP, H?pital Bichat, Centre d?ˉInvestigation Clinique||Universit¨| de Paris||AP-HP, H?pital Bichat, Centre de Ressources BiologiquesMolecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Universit¨| de Paris, Institut Pasteur||National Reference Center for Respiratory Viruses, Institut PasteurAP-HP, H?pital Bichat, Centre d?ˉInvestigation CliniqueUniversit¨| de Paris||AP-HP, H?pital Bichat, Equipede Pr¨|vention du Risque InfectieuxBiologie cellulaire des lymphocytesMolecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Universit¨| de Paris, Institut Pasteur||National Reference Center for Respiratory Viruses, Institut PasteurPaediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St George?ˉs University of London||Paediatric Pharmacology and Paediatric Infectious Diseases, University of Basel Children?ˉs 5HospitalUniversit¨| de Paris||AP-HP, H?pital Bichat, Service de Maladies Infectieuses et tropicalesAP-HP, H?pital Bichat, Centre d?ˉInvestigation CliniqueAP-HP, H?pital Bichat, Laboratoire de VirologieUniversit¨| de Paris||Center for Interdisciplinary Research in Biology (CIRB), Coll¨¨ge de FranceJulius Center for Health Sciences and Primary Care, University Medical Center UtrechtCIRI, Centre International de Recherche en Infectiologie, (Team VirPath)||Laboratoire de Virologie, Centre National de R¨|f¨|rence des Virus des infections respiratoires (dont la grippe), Institut des Agents Infectieux, Groupement Hospitalier Nord
医学研究方法预防医学临床医学
SARS-CoV-2healthcare workershigh-risk exposurepersonal protective equipmenttransmission
Burdet Charles,Manchon Pauline,Charpentier Charlotte,Guedj J¨|r¨|mie,Descamps Diane,Leclercq Anne,Attia Mika?l,Demeret Caroline,Goossens Herman,Duval Xavier,Tubiana Sarah,Behillil Sylvie,Thy Michael,Lucet Jean-Christophe,Rose Thierry,van der Werf Sylvie,Bielicki Julia Anna,Yazdanpanah Yazdan,Alavoine Loubna,Houhou Nadhira,Blanquart Fran?ois,Bruijning-Verhagen Patricia,Lina Bruno.High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in healthcare workers: results of the CoV-CONTACT prospective cohort[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2020.09.17.20194860.点此复制
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