鲤鱼多聚免疫球蛋白受体pIgR的组织分布

Polymeric immunoglobulin receptor (pIgR) is a kind of transmembrane protein which mediates the transportation of polymeric immunoglobulins across the mucosal epithelial cells and protects them from proteolytic degradation. It plays an important role in mucosal immunity. In this paper, we studied the distribution of pIgR in mucosal tissues of carp with molecular biology and immunohistochemical techniques. The results revealed that the mRNA was highly expressed in intestine, gill, skin and other mucosal tissues of carp while the protein mainly distributed in the basolateral surface of intestine epithelial cells. This study will benefit further researching of the immunological function of fish pIgR.