一种新型铁载体荧光探针的设计、合成与初步应用研究

he bacterial resistance problem caused by the abuse of antibiotics becomes more and more serious. Currently, it is urgent to develop efficient pathogen-specific identification methods to guide clinical medication and reduce the scope of antibiotics.By utilizing the active transport of natural antibiotic albomycin\'s siderophore in bacteria, this paper develops a novel NBD-siderophore fluorescent probeto realize the identification of a certain kind of bacteria.The probe uses NBD as the fluorescent light-emitting part, which is simple to purify, and can generate green fluorescence with an emission wavelength of 535nm under 465nm excitation light.After binding iron ions, the fluorescence luminescence performance of the probe is maintained.Preliminary fluorescence staining screening experiments show that the probe can enter Yersinia enteritidis and has the potential to has the potential to become a specific fluorescent probe for Yersinia enterocolitica.