表面活性蛋白-D rs3088308、rs721917位点基因多态性与矽肺易感性的关系
目的 探讨表面活性蛋白-D rs3088308与rs721917位点基因多态性与河南地区某铁矿男性接尘作业人员矽肺易感性的关系。方法 采用1∶1配对病例-对照研究方法，以确诊的125例矽肺病人为病例组，以健康接尘工人为对照组，按同年龄、同性别、同工种、相同累积接尘工龄进行配对，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测表面活性蛋白-D基因rs3088308与rs721917两位点基因型。结果 SP-D rs3088308位点病例组T/T、T/A、A/A基因型频率分别为22.2%、71.2%、5.6%，T、A等位基因频率分别为58.8%、41.2%，对照组T/T、T/A、A/A基因型频率分别为17.6%、58.4%、24.0%，T、A等位基因频率分别为46.8%、53.2%，两组间基因型与等位基因频率分布的差异均有统计学意义（P0.05）。结论SP-D rs3088308位点基因多态性可能与矽肺易感性有关联，而rs721917位点基因多态性可能与矽肺易感性无关。
Objective To investigate the relationship between polymorphisms of surfactant protein D (rs3088308 and rs721917) and the susceptibility to silicosis. Methods This case-control study included 125 silicosis patients and 125 individuals exposed to industrial dust but without silicosis (control group), who were strictly matched with the case group for age, gender, worktype and cumulative length of dust exposure. The rs3088308 and rs721917 polymorphisms of surfactant protein-D were detected in all the participants using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The frequencies of T/T, T/A and A/A genotypes of surfactant protein-D rs3088308 locus were 22.2%, 71.2% and 5.6% in the case group, significantly different from the frequencies of 17.6%, 58.4% and 24.0% in the control group, respectively (P0.05). Conclusion Surfactant protein-D rs3088308 polymorphism is significantly associated with silicosis, and the T allele may be a risk factor for silicosis in individuals exposed to industrial dust.
郝小惠、王宏丽、刘和亮、吴传文、郭志义、张秀峰、刘微、郭灵丽
基础医学预防医学矿山安全、矿山劳动保护
矽肺表面活性蛋白-D：基因多态性易感性
郝小惠,王宏丽,刘和亮,吴传文,郭志义,张秀峰,刘微,郭灵丽.表面活性蛋白-D rs3088308、rs721917位点基因多态性与矽肺易感性的关系[EB/OL].(2017-12-27)[2025-08-16].https://chinaxiv.org/abs/201712.00907.点此复制
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