以邻炔基萘酚为骨架的喹啉类衍生物的合成

Quinolines are structures that are widely found in natural products, pharmaceuticals, and biologically active molecules.O-alkynyl naphthol is the precursor compound of VQM (Vinylidene o-quinone methide), which is a kind of reaction intermediate with high reactivity and multiple reactive sites. In this work, the quinoline structure was introduced into the ortho-alkynyl naphthol skeleton, and the quinoline derivative was synthesized, which provided substrate for the subsequent exploration of reactions based on VQM.